ROLE OF AUTOPHAGY AND HISTORY OF ITS DISCOVERY

About the authors:

Specialist student, University of Tyumen, MoriaKoto1998@gmail.com

Abstract:

This article is devoted to the process of autophagy and mechanisms underlying it. The article presents information on the history of phenomenon’s discovery and researches that have opened a new path in understanding of autophagy’s fundamental importance in many physiological aspects, such as adaptation to starvation and infection response. The main purpose of the article is to get acquainted with new, recently discovered autophagosome’s functions in cells of living organisms, as well as to understand the mechanism underlying autophagosome formation.

References:

1.     Press Release - The Nobel Prize in Physiology and Medicine. 2016.

2.     Takeshige,K.,  Baba,M., Tsuboi,S., Noda,T. and      Ohsumi,Y. (1992) Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. Journal of Cell Biology, 119, pp.301-311.

3.     Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M.D., Klionsky, D.J., Ohsumi, M. and Ohsumi, Y. (1998) A protein conjugation system essential for autophagy. Nature, 395, pp.395-398.

4.     Tsukada, M. and Ohsumi, Y. (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cervisiae. FEBS Letters, 333, pp.169-174.